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Project Details

Determinants of Protection and Enhancement of Dengue Infection/Disease in Vivo

Project Summary: 

The goals of this project are to address critical questions about the role of serotype-, domain-, and epitope-
specific antibody responses in protection or enhancement of DENV infection in vivo using our dengue mouse
model. We will also determine which B cell epitopes, as well as which memory T and B cell subsets, play a
significant role in protection and/or enhancement in secondary DENV infection.

Project Type: 
Populations: 
Contact Person: 
Josefina Coloma
Contact Person's Email Address: 
colomaj@berkeley.edu
Department/Center: 
IDV
Principal Investigators: 
Eva Harris
Funder/Client: 
NIAID, NIH
Publication Date: 
2011